Can apps help to fight the SARS-CoV-2 pandemic?

Summary:

  1. Two different types of apps are currently put forward: Survey apps and contact tracer apps.
  2. Survey apps aim to give researchers and politicians real-time population-level access to the spread of the virus. This is done via a series of questions about the user’s symptoms.
  3. The goal of contact tracer apps is to alert individuals if they have been in close contact with a virus carrier. This is achieved by detecting and recording the user’s every close contact with another user via Bluetooth on their phones.
  4. Both types of apps have been shown to be effective in managing the spread of the virus in controlled scientific studies.
  5. Concerns regarding data safety and efficacy in real-life scenarios have been raised by data safety experts and ethics-researchers.
  6. It is advised to check official sources (e.g. government websites) to obtain information on which apps to use in specific countries.

An increasing number of countries are partially lifting the acute social isolation measures taken at the beginning of the COVID-19 pandemic. However, the global infection rate is still constant at almost 100,000 new cases per day [1]. With the need to return to some sort of normality [2] but with whole-population-testing being impractical, politicians and experts are looking at smartphone apps as tools to make virus countermeasures more targeted and effective.

In general, the usage of such apps is voluntary, and the proposed apps can be divided into survey apps and contact tracer apps.

The aim of survey apps is to estimate whether an individual is infected with SARS-CoV-2 via a series of questions regarding the user and their symptoms. Together with location data, this data is pseudonymised* and shared with a central database. Scientists can then use this data, for instance to model where the epicentres of the spread are and how they develop [3]. This information is crucial to guide effective countermeasures and, yet, difficult to obtain on the same scale with classical methods [4]. However, since the diagnosis of COVID-19 is only based on user inquiry and not on medical tests, it is only effective on a population level and not as a test for individuals [5]. Moreover, scientists face several statistical challenges when working with app-based data, such as not having control over the social groups that are contributing to the data – e.g. infants and elderly are most likely underrepresented [5].

Contact tracer apps are intended to guide self-isolation for individuals by informing them if they have been in contact with a COVID-19 positive person. This is achieved in the following way: The app-user has the app installed on their smartphone. When they come into close contact with another app-user, their phones log this by exchanging user IDs via Bluetooth. If one of the users later reports a positive COVID-19 test, the other user is notified and asked to self-isolate. It is important to note that no information about the identity of the positive user is shared in this notification. In addition to allowing for ‘informed isolation’, this system also allows researchers to track the spread of the virus in detail and it has been shown that contact tracing can be an effective tool for epidemiologists [6]. However, even though theoretical studies show that contact tracer apps can be an efficient tool against the spread of COVID-19 [7], user participation and tracing proximity precision are major challenges that need to be overcome for such apps to be effective [8].
Moreover, due to the personal and sensitive nature of the collected data, contact tracer apps need to adhere to the highest data protection standards [9]. In this context, these apps can be categorised in ‘centralised’ and ‘decentralised’ architectures. Centralised contact tracer apps share the user’s health status and all contacts with other users with a central database, which computes whether a user was in contact with a positive user and reports only this information. Decentralised apps store user contacts locally (on the smartphone) and only share the health status with the database, which in turn gives access to a complete list of all users’ (pseudonymised) health status. The app then computes potential contacts with positive users locally. Data safety experts strongly recommend decentralised contact tracer apps [10, 11].

Mobile apps can be powerful tools to track the spread of the SARS-CoV-2 virus and inform us about the potential need for self-isolation.
Mobile apps can be powerful tools to track the spread of the SARS-CoV-2 virus and inform us about the potential need for self-isolation.

Generally, there has been a rise of apps related to the COVID-19 pandemic and, while many of them are developed in cooperation with healthcare experts, some are designed to defraud the user using malware [12]. Therefore, it is important to consult official sources (e.g. the website of one’s government) for advice on which apps to use before installing any.

In summary, apps can be a powerful tool for politicians and researchers to survey the development of the COVID-19 pandemic and to guide effective countermeasures. Moreover, informed isolation through contact tracing can be an effective strategy to minimise the spread of the virus while relaxing general lockdown. However, since the data collected by those apps contains personal medical and location information, it is imperative that those apps comply with the highest data safety standards. It remains to be seen how well COVID-19 apps will perform under real-life conditions.

* to replace something in data that identifies an individual with an artificial identifier, in a way that allows re-identification

References:

  1. WHO, Coronavirus disease (COVID-19) Situation Report – 116. 2020, World Health Organization.
  2. Brunier, A., et al., Substantial investment needed to avert mental health crisis. 2020, World Health Organisation.
  3. Menni, C., Real-time tracking of self-reported symptoms to predict potential COVID-19, Nature Medicine, 2020.
  4. Rossmann H., A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys, Nature Medicine, 2020.
  5. Drew, D.A., Nguyen, L.H., et al., Rapid implementation of mobile technology for real-time epidemiology of COVID-19, Science, 2020.
  6. Bi, Q., et al., Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study, The Lancet Infectious Diseases, 2020.
  7. Feretti, L., Wymant, C., et al., Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing, Science, 2020
  8. Stewart, A., Ensuring contact tracing apps are effective, responsive and part of an integrated publication health response to reduce R, Oxford University Media Update, 2020.
  9. Parker, M.J., et al., Ethics of instantaneous contact tracing using mobile phone apps in the control of the COVID-19 pandemic, Journal of Medical Ethics, 2020.
  10. Troncoso, C., et al., Decentralized Privacy-Preserving Proximity Tracing, 2020.
    https://github.com/DP-3T/documents
  11. Fraser, C., Digital contact tracing: comparing the capabilities of centralised and decentralised data architectures to effectively suppress the COVID-19 epidemic whilst maximising freedom of movement and maintaining privacy,
    https://github.com/BDI-pathogens/covid-19_instant_tracing
  12. Hazum, A., COVID-19 goes mobile: Coronavirus malicious applications discovered, cp<r> Check Point Research, 2020.