CRISPR/Cas9 series: a compelling journey from a primitive bacterial defence system to an advanced human gene-editing technology

The side effects of CRISPR / Cas9 and the current strategies to mitigate them Summary: The CRISPR/Cas9 system often not only cuts at the intended site of the genome, but also in other unwanted places, which are called off-targets; Off-target events are mainly due to sequence homology between sgRNA and genomic DNA other than the target one, as well as […]